Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 23;11:15073. doi: 10.1038/s41598-021-94499-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

ERRα deficiency leads to alterations in fecal microbiota diversity and composition. (a) Analysis of the microbiome alpha diversity in the fecal pellets of WT mice or Esrra^−/− mice collected at baseline (day 0—untreated) or at different time points after 3% DSS treatment. Kruskal–Wallis for all groups, p < 0.01. (b) Bacterial genera (the phylum name is indicated under the genus name) with significant differences in abundance levels (ANCOM test) in the fecal pellets of WT mice versus Esrra^−/− mice, day 6 is illustrated. Differences in operational taxonomic units (OTUs) between WT and Esrra^−/− mice at different time points in the DSS experiment in Akkermansia muciniphila (c), Sutterella (d), and Proteobacteria (e). Data represent the mean ± SEM of n = 4 mice/genotype. Statistical analysis was performed using Student’s t-test, *p < 0.05. ns, not significant.