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. 2021 Jul 23;11:407. doi: 10.1038/s41398-021-01527-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Common genetic variants associated with both BIP and (A) BMI, (B) SBP, (C) DBP, (D) TC, (E) LDL, (F) HDL, (G) T2D, and (H) CAD at conjFDR<0.05. Manhattan plot showing the –log10 transformed conjFDR values for each SNP on the y-axis and chromosomal positions along the x-axis. SNPs with conjunction FDR<0.05 (i.e., −log10 FDR>1.3) are shown with enlarged data points. A black circle around the enlarged data points indicates the most significant SNP in each LD block. Further details are provided in Supplementary Tables. BIP bipolar disorder, CVD cardiovascular disease, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, LDL low-density lipoprotein cholesterol, HDL high-density lipoprotein cholesterol, T2D type 2 diabetes, CAD coronary artery disease, conjFDR conjunctional FDR. The results of BIP & BMI at conjFDR<0.01 are previously presented in Bahrami et al. [24].

Fig. 2 — Common genetic variants associated with both BIP and (A) BMI, (B) SBP, (C) DBP, (D) TC, (E) LDL, (F) HDL, (G) T2D, and (H) CAD at conjFDR<0.05. Manhattan plot showing the –log10 transformed conjFDR values for each SNP on the y-axis and chromosomal positions along the x-axis. SNPs with conjunction FDR<0.05 (i.e., −log10 FDR>1.3) are shown with enlarged data points. A black circle around the enlarged data points indicates the most significant SNP in each LD block. Further details are provided in Supplementary Tables. BIP bipolar disorder, CVD cardiovascular disease, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, LDL low-density lipoprotein cholesterol, HDL high-density lipoprotein cholesterol, T2D type 2 diabetes, CAD coronary artery disease, conjFDR conjunctional FDR. The results of BIP & BMI at conjFDR<0.01 are previously presented in Bahrami et al. [24].