Table 2.
Shared loci between bipolar disorder and cardiovascular disease phenotypes.
| Associated phenotype | Shared loci (n) conjFDR | Concordant effect (%) | Genetic correlation |
|---|---|---|---|
| CVD phenotypes | |||
| BMIa | 69 | 52.2% | −0.06 (p = 0.010) |
| SBP | 53 | 49.1% | 0.02 (p = 0.396) |
| DBP | 53 | 47.2% | 0.04 (p = 0.155) |
| TC | 15 | 26.7% | 0.02 (p = 0.463) |
| LDL | 13 | 46.2% | 0.03 (p = 0.346) |
| HDL | 10 | 40.0% | −0.02 (p = 0.471) |
| T2D | 4 | 25.0% | −0.04 (p = 0.422) |
| CAD | 10 | 70.0% | −0.02 (p = 0.539) |
Number of shared loci at conjFDR<0.05, concordant effect directions in percentage, and genetic correlation estimated by LD score regression.
BIP bipolar disorder, CVD cardiovascular disease, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, TC total cholesterol, HDL high-density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, T2D type 2 diabetes mellitus, CAD coronary heart disease, conjFDR conjunctional FDR.
aThe results for BMI & BIP are retrieved from Bahrami et al. [24].