Fig. 4. CA170 treatment enhances intracellular cytokine levels induced by Kvax in CD4⁺ and CD8⁺ T cells from lung tumors.

Lung tumors were processed into single cells at the endpoint of the experiment and flow cytometric analysis was conducted after stimulation with Kras peptide in the presence of monesin and brefeldin A. A, B Flow cytometric dot plots and C, D corresponding graphs depicting the amounts of cytokines granzyme B, IFNγ and TNFα measured by intracellular cytokine staining. Data are shown as the mean ± SE, n = 5, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 vs Ctrl.