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. 2021 Jul 23;11:15075. doi: 10.1038/s41598-021-94566-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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KC (LSL:Kras^G12D:Pdx1-CRE) mouse model. (a) Schematic representation of the genetic construct for conditional Kras^G12D expression under the control of Pdx1 promoter (CRE-Lox system). Primers used for Kras^G12D conditional PCR are noticed. (b) Top: Kras^G12D conditional PCR showing LSL cassette recombination in pancreas, but not tail, from KC mouse, and not in WT mouse. Bottom: Kras^G12D genotyping PCR showing heterozygosity in KC mice (WT and Kras^G12D alleles) and homozygosity in WT mouse (WT allele). Uncropped gels are provided in Supplementary Figure S2.