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. 2021 Jul 23;11:15075. doi: 10.1038/s41598-021-94566-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immune dysregulation in mice suffering from thymic lymphoma development. (a) Representative images of histological analysis of spleen from KC mice presenting or not thymic mass (H&E staining and Ki67 and KRAS^G12D immunohistochemistry). (b) Image showing enlarged spleen from KC mouse with thymic mass. (c) Representative images of histological analysis of the pancreas of KC mouse without thymic lymphoma, and one of the two mice with thymic mass which presented high level of immune infiltration (H&E staining and CK19, Ki67, CD3e and KRAS^G12D immunolabelings). (d) Representative images of histological analysis of the proximal lymph node of one of the two mice with thymic mass which presented high level of immune infiltration (H&E staining and CK19, Ki67, CD3e and KRAS^G12D immunolabelings). Scale bars are indicated on the pictures.