Table 2.
Representative mutations that were commonly fixed in the evolved strains.
| Anti-TB drugs | Effect | Locus tag | Ortholog in MTB* | Description | Previously reported** |
|---|---|---|---|---|---|
| BDQ | Non-synonymous | AT701_RS24130 | atpE | ATP synthase Fo subunit C | Y |
| CFZ | Promoter | AT701_RS31085/AT701_RS31090 | Metallophosphoesterase/hypothetical protein | ||
| CMZ | |||||
| DCS | Non-synonymous | AT701_RS01985 | EamA family transporter | ||
| Non-synonymous | AT701_RS01990 | PLP-dependent aminotransferase family protein | |||
| EMB | Non-synonymous | AT701_RS31290 | embC | Arabinosyltransferase C | Y |
| Promoter | AT701_RS31295 | embA | Arabinosyltransferase A | Y | |
| Non-synonymous | AT701_RS3130 | embB | Arabinosyltransferase B | Y | |
| INZ | Non-synonymous | AT701_RS15800 | inhA | NADH-dependent enoyl-ACP reductase | Y |
| Frame-shift | AT701_RS3127 | katG | Catalase-peroxidase | Y | |
| LZD | Frame-shift | AT701_RS07195 | oxiR | TetR/AcrR family transcriptional regulator | N |
| MP | Promoter | AT701_RS30910 | Rv2864c | Penicillin-binding protein | N |
| Non-synonymous | AT701_RS30910 | Rv2864c | Penicillin-binding protein | N | |
| Frame-shift | AT701_RS31385 | Rv3811 | Putative N-acetylmuramoyl-l-alanine amidase | N | |
| TRZ | Non-synonymous | AT701_RS13855 | Rv2707 | YihY/virulence factor BrkB family protein | N |
| RIF | Non-synonymous | AT701_RS07130 | rpoB | DNA-directed RNA polymerase subunit beta | Y |
*Orthlog genes in M. tuberculosis H37Rv strain are shown.
**Genomic mutations of M. tuberculosis associated with drug resistance are indicated as Y (others are indicated as N) based on the previous report (Lange et al.7).