Table 2.
Hazard ratio for bladder cancer in relation to consumption of cruciferous vegetables stratified by quintile of reported consumption
| Broccoli | Cauliflower/Brussel Sprouts | Composite/Total Cruciferous | |||||
|---|---|---|---|---|---|---|---|
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| n | Fully Adjusted HR (CI) | n | Fully Adjusted HR (CI) | n | Fully Adjusted HR (CI) | ||
| All Bladder Cancer | Quintile 1 | 2,081 | ref | 1,920 | ref | 2,016 | ref |
| Quintile 2 | 1,362 | 0.991 (0.920, 1.066) | 1,478 | 1.007 (0.936, 1.084) | 1,714 | 1.022 (0.953, 1.095) | |
| Quintile 3 | 1,933 | 1.007 (0.941, 1.077) | 1,800 | 1.003 (0.936, 1.076) | 1,613 | 0.986 (0.917, 1.060) | |
| Quintile 4 | 2,058 | 1.024 (0.956, 1.097) | 1,756 | 1.019 (0.949, 1.094) | 1,667 | 1.021 (0.949, 1.100) | |
| Quintile 5 | 1,133 | 1.083 (0.989, 1.185) | 1,613 | 1.064 (0.984, 1.149) | 1,557 | 1.082 (0.990, 1.182) | |
| p trend (p value) | 0.214 | 0.479 | 0.262 | ||||
| High Grade Bladder Carcinoma | Quintile 1 | 798 | ref | 770 | ref | 785 | ref |
| Quintile 2 | 543 | 1.026 (0.911, 1.154) | 545 | 0.927 (0.824, 1.042) | 679 | 1.066 (0.953, 1.191) | |
| Quintile 3 | 739 | 1.025 (0.919, 1.144) | 707 | 0.97 (0.868, 1.085) | 589 | 0.955 (0.849, 1.074) | |
| Quintile 4 | 789 | 1.037 (0.927, 1.160) | 620 | 0.911 (0.811, 1.023) | 615 | 1.002 (0.887, 1.131) | |
| Quintile 5 | 395 | 1.068 (0.920, 1.239) | 622 | 1.053 (0.930, 1.193) | 596 | 1.184 (1.025, 1.367) | |
| p trend (p value) | 0.754 | 0.550 | 0.224 | ||||
| Low Grade Bladder Carcinoma | Quintile 1 | 946 | ref | 844 | ref | 898 | ref |
| Quintile 2 | 601 | 0.974 (0.873, 1.088) | 683 | 1.045 (0.937, 1.165) | 854 | 0.99 (0.891, 1.099) | |
| Quintile 3 | 884 | 0.993 (0.898, 1.098) | 811 | 1.03 (0.928, 1.144) | 762 | 1.028 (0.925, 1.143) | |
| Quintile 4 | 929 | 1.01 (0.913, 1.119) | 852 | 1.105 (0.995, 1.226) | 787 | 1.05 (0.943, 1.170) | |
| Quintile 5 | 547 | 1.04 (0.912, 1.187) | 717 | 1.029 (0.916, 1.155) | 706 | 0.995 (0.874, 1.133) | |
| p trend (p value) | 0.729 | 0.762 | 0.754 | ||||
| Fatal Bladder Carcinoma | Quintile 1 | 333 | ref | 279 | ref | 314 | ref |
| Quintile 2 | 195 | 0.877 (0.724, 1.064) | 207 | 1.002 (0.826, 1.216) | 241 | 0.95 (0.791, 1.141) | |
| Quintile 3 | 268 | 0.873 (0.731, 1.043) | 283 | 1.076 (0.897, 1.291) | 220 | 0.901 (0.744, 1.092) | |
| Quintile 4 | 279 | 0.893 (0.745, 1.071) | 226 | 0.911 (0.750, 1.107) | 237 | 0.984 (0.809, 1.197) | |
| Quintile 5 | 158 | 1.023 (0.808, 1.296) | 238 | 1.146 (0.934, 1.406) | 221 | 1.103 (0.873, 1.394) | |
| p trend (p value) | 0.599 | 0.874 | 0.896 | ||||
| Localized Bladder Carcinoma | Quintile 1 | 594 | ref | 553 | ref | 554 | ref |
| Quintile 2 | 372 | 0.992 (0.863, 1.141) | 377 | 0.85 (0.738, 0.979) | 460 | 1.056 (0.924, 1.206) | |
| Quintile 3 | 481 | 0.911 (0.798, 1.040) | 453 | 0.873 (0.763, 0.998) | 398 | 0.913 (0.791, 1.053) | |
| Quintile 4 | 534 | 0.995 (0.872, 1.136) | 442 | 0.888 (0.774, 1.018) | 407 | 0.985 (0.851, 1.140) | |
| Quintile 5 | 278 | 0.998 (0.836, 1.191) | 434 | 1.023 (0.883, 1.184) | 440 | 1.234 (1.041, 1.462) | |
| p trend (p value) | 0.491 | 0.491 | 0.059 | ||||
| Advanced Bladder Carcinoma | Quintile 1 | 105 | ref | 113 | ref | 105 | ref |
| Quintile 2 | 87 | 1.423 (1.044, 1.941) | 63 | 0.743 (0.534, 1.034) | 97 | 1.157 (0.858, 1.560) | |
| Quintile 3 | 92 | 1.1 (0.807, 1.500) | 96 | 0.973 (0.726, 1.303) | 71 | 0.943 (0.681, 1.307) | |
| Quintile 4 | 103 | 1.233 (0.903, 1.682) | 87 | 0.932 (0.688, 1.262) | 97 | 1.251 (0.912, 1.715) | |
| Quintile 5 | 52 | 1.282 (0.854, 1.925) | 80 | 0.93 (0.663, 1.306) | 69 | 1.07 (0.718, 1.594) | |
| p trend (p value) | 0.634 | 0.620 | 0.785 | ||||
| In Situ Bladder Carcinoma | Quintile 1 | 646 | ref | 573 | ref | 593 | ref |
| Quintile 2 | 403 | 0.976 (0.854, 0.115) | 466 | 1.043 (0.915, 1.189) | 540 | 1.067 (0.941, 1.210) | |
| Quintile 3 | 599 | 1.02 (0.903, 1.151) | 542 | 0.983 (0.866, 1.116) | 501 | 1.031 (0.906, 1.174) | |
| Quintile 4 | 603 | 0.968 (0.854, 1.098) | 553 | 1.052 (0.926, 1.195) | 512 | 1.035 (0.906, 1.184) | |
| Quintile 5 | 359 | 1.125 (0.958, 1.322) | 476 | 1.007 (0.874, 1.161) | 464 | 1.04 (0.886, 1.222) | |
| p trend (p value) | 0.271 | 0.722 | 0.764 | ||||
Abbreviations: n: number; HR: Hazard Ratio; CI: Confidence Interval; ref: reference.