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. 2021 Jul 20;10(7):1835. doi: 10.3390/cells10071835

Figure 2.

Figure 2

Electrophysiological characterization of Cttn-knockout mice. (A,B) Characterization of basal synaptic transmission via measurements of excitatory postsynaptic potentials (EPSP) as well as input-output measurements (‘Fiber Volley’, FV) in acute hippocampal slices from WT and Cttn-deficient animals. (C) Analysis of short-term plasticity in WT and Cttn-KO acute hippocampal slices as evaluated by paired-pulse facilitation (PPF). (D) Long-term potentiation induced via theta-burst stimulation (TBS) after 20 min of baseline recording at the Schaffer collateral to CA1 pathway in acute hippocampal slices derived from WT and Cttn-KO mice. Representative single fEPSP responses are shown for (a) WT Ctrl (b) WT LTP (c) Cttn KO Ctrl (d) Cttn KO LTP. Scale Y = 1 mV, X = 5 ms. Data information: n = number of slices; Statistic tests used: For normal distribution of data: Kolmogorov-Smirnov Test, Parametric Tests: Two-Way ANOVA and Sidak’s Multiple Comparisons, Non-Parametric Tests: Kruskal-Wallis Test and Dunn’s test or Student’s T-Test; data depicted as means ± SEM, detailed information on p values as well as statistical tests is depicted in Table S1; significances are indicated by *** p value < 0.001.