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. 2021 Jul 19;26(14):4363. doi: 10.3390/molecules26144363

Table 5.

Optimal MAE conditions for tobacco leaves and tobacco waste obtained by response surface methodology.

Leaves Scrap Dust Midrib
Criteria: Maximum extraction yield with maximum nicotine content
Temperature (°C) 80.0 80.0 80.31 80.0
Time (min) 5.0 5.0 5.0 25.0
Solvent/solid ratio (mL/g) 26.1 29.8 30.01 30.00
Predicted yield value (%) 68.624 49.868 48.888 53.455
Predicted nicotine value (%) 5.638 3.268 4.058 1.603
Criteria: Maximum extraction yield with minimum nicotine content
Temperature (°C) 120.0 120.0 119.3 120.0
Time (min) 25.0 25.0 19.4 11.2
Solvent/solid ratio (mL/g) 10.0 19.1 30.0 30.0
Predicted yield value (%) 66.123 68.315 58.233 55.961
Predicted nicotine value (%) 2.311 1.870 2.628 1.045