Figure 3.

Schematics of a mid-sagittal section through the mandibular and hyoid arches of a mouse embryo at E12. Bmp4 is expressed in the distal mandibular epithelium, at the site of presumptive incisors, while Msx1 is expressed in the distal mandibular ectomesenchyme, surrounding the incisor primordia. Shh is expressed in the vestibular lamina and dental epithelium, as well as in the lingual epithelium, while Foxf1/Foxf2 are expressed in ectomesenchyme in the medial region of the mandibular process, surrounding the incisor primordium and inside the nascent tongue. Pax3 is expressed in the ectomesenchyme of distal tip of the mandibular process and nascent tongue. Lhx6/Lhx8 are expressed in ectomesenchyme on the rostral side, while Gsc is expressed on the caudal side of the mandibular process. Meis2 is expressed in the medial proximal region of the mandibular process and in the medial region of the hyoid arch. Abbreviations: E, embryonic day; MC, Meckel’s cartilage; HB, cartilage primordium of the hyoid bone. Expression domains of genes written in black text are not highlighted in the figure.