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. 2021 Jun 23;11(7):413. doi: 10.3390/metabo11070413

Figure 1.

Figure 1

Typical summed spectra measured with 1H MRS (a,d), 2H MRS (b,e) and HP 13C MRS (c,f) under isoflurane solely (‘ISO’, in green) and under medetomidine combined with isoflurane anesthesia (‘MED–ISO’, in red). In (c,f), the glycolytic intermediate 3-phosphoglycerate (3PG, 179.8 ppm) can be identified in the summed spectra in addition to the C1-Lac at 183.5 ppm. The broad peak at 175 ppm designated by (*) is an impurity in the HP [2H7, U-13C6] Glc powder. Significant differences between the two anesthesia groups are found in endogenous Lac concentration measured by 1H MRS (g), in lactate/HDOmean measured by 2H MRS (h), and in Lac-to-Glc ratio (LGR) measured by HP 13C MRS (i).