Table 3.

microRNAs that are involved in cardiomyocyte cell cycle entry.

miRNA	Studied Species	Highlights	References
miR-302-367	Transgenic mice	miR-302-367 overexpression promoted cardiomyocyte proliferation and reduced scar size after MI	[68]
miR-499	P19CL6 cells	miR-499 regulated the proliferation and apoptosis of P19CL6 cells in the late stage of cardiac differentiation	[67]
miR-199a	AAV overexpressing mirRNA199a	miR-199a overexpression promoted cardiomyocyte cell cycle entry in mice, rats, and pigs and induced almost complete recovery of cardiac function parameters after MI Long-term expression of miR199a resulted in cardiac death	[64,69]
miR-128	KO mice	Neonatal cardiomyocyte KO miR-128 showed prolonged proliferation Adult KO mice showed improved scar size and cardiac function after MI	[65]
miR-294	AAV overexpression	miR-294 overexpression promoted cardiomyocyte cell cycle entry	[66]