Figure 4.

Classification of relevant CRF-associated plasma metabolites to major and specific metabolic pathways. Top: females; bottom: males. Major metabolic pathways are color-coded as follows: amino acid metabolism (dark blue); carbohydrate metabolism (yellow); energy metabolism (light blue); lipid metabolism (brown). * findings from confounder (age/menopausal status)-adjusted bi-/multivariate association analyses; ** findings from bivariate association analyses additionally adjusted for phenotypical/clinical variables. CRF: cardiorespiratory fitness; PC: phosphatidylcholine; SM: sphingomyelin. Metabolites with bivariate correlations to CRF that were significantly different from zero in both females and males are indicated in bold.