Scheme 5.
The synthesis of hydrophilic cytotoxic agent (68) containing PEG linker. Reagents and conditions: (a) HBr/AcOH; (b) Et3N, r.t.; (c) 1,4-dioxane, 80 °C; (d) DECP/DIPEA, r.t.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.