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Antitumor activity of multiunit modified Dol-10 derivatives. Position: Dov1-Val2-Dil3-Dap4-Doe5.
| Compound | Modified Position | ILSmax * | Optimal Dose (mg/kg per inj.) |
|---|---|---|---|
| 1 | 50 | 0.05 | |
| 73 | 1 | 94 | 0.5 |
| 77 | 2 | 80 | 0.5 |
| 81 | 3 | 74 | 2.0 |
| 85 | 5 | 83 | 0.5 |
* Maximal increase in life span (please refer to Reference [110]).
