Table 1.
The most important findings in the field of MRT induced response in different tumour models.
| Tumor Model | Assay Type | MRT Effects on Tumor Immune Response | Reference |
| Glioblastoma in rat | Oligonucleotide microarray | Upregulation of genes associated with inflammation, NK or CD8+ T cells | Bouchet et al., 2013 [88] |
| Glioblastoma in rat | Oligonucleotide microarray | Upregulation of transcripts indicating the presence of DCs, monocytes, and macrophages | Bouchet et al., 2014 [89] |
| Glioblastoma in rat | IHC | Increase of infiltrated macrophages | Eling et al., 2021 [101] |
| Mammary EMT6.5 in mouse | Whole genome analysis | Upregulation of genes related to inflammation, IFN signalling, antigen presentation |
Sprung et al., 2012 [87] |
| Mammary EMT6.5 cell line | Whole genome analysis | Upregulation of pathways involved in inflammation and lymphocyte activation | Yang et al., 2014 [90] |
| Mammary EMT6.5 in mouse | Flow cytometry, IHC | Decrease in tumour-associated macrophages and neutrophils; increase of infiltrated T cells |
Yang et al., 2019 [96] |
| Melanoma B16F10 in mouse | Cytokine BioPlex analysis, IHC | Increase of monocyte-attracting cytokines; Increase of infiltrated macrophages, CD4+ and CD8+ T cells, NK cells | Potez et al., 2019 [47] |
| Melanoma B16F10 in mouse | IHC | Presence of melanophages at the place of tumor cells and absence of metastasis up to 18 months post-treatment | Fernandez-Palomo et al., 2020 [48] |