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. 2021 Jun 25;11(7):615. doi: 10.3390/life11070615

Figure 3.

Figure 3

The structure of non-structural protein 1 (NS1). (a) The dimer structure of the NS1 protein of Zika virus (ZIKV). Two NS1 monomers are combined in the head-to-head form to produce dimers of NS1, and the β chain is extended and tiled into a larger plane (Protein Data Bank [PDB]: 5IY3 ZIKV). (b) The domains of the NS1 dimer protein of West Nile virus (WNV). NS1 protein contains three structural units, namely β-roll, β-ladder, and wing, which are, respectively indicated in blue, orange, and yellow; each monomer has three glycosylation sites (red): asn130, asn175, and asn207 (PDB: 4O6C WNV). (c) An octapeptide sequence in the C-terminal of NS1 plays an important role in cleavage; thus, it can be used as a target of antiviral therapy. Arrows indicate potential therapeutic targets (PDB: 4O6C WNV).