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. 2021 Jun 25;11(7):615. doi: 10.3390/life11070615

Figure 5.

Figure 5

Anti-flavivirus compounds. (a) 4-(guanidinomethyl)-phenylacetyl-Arg-Tle-Arg-4-aminoboenzylamide (MI-1148) is a furin protease inhibitor which blocks the cracking of furin and weakens the toxicity of viral protein. (b) Compound 3 is an allosteric inhibitor which blocks the interaction between non-structural protein 2B (NS2B) and NS3. (c) ST-610 prevents adenosine triphosphate (ATP) hydrolysis in the cell culture of dengue virus (DENV). (d) Sinefungin is a natural product that potently inhibits the activity of flavivirus; however, like S-adenosylmethionine (SAM), it can produce cytotoxicity. The amino acids of flavivirus that interact with sinefungin are shown in the structure (PDB: 5KQS). (e) NSC12155 inhibits SAM by binding to the SAM cofactor site of the methyltransferase (MTase) (PDB: 5CUQ). (f) Compound 21 is a 2,6-diaminopurine derivative which inhibits the NS5 RNA-dependent RNA polymerase (RdRp) of DENV. (g) Compound 27 binds to the allosteric site of RdRp and inhibits the replication of dengue virus type 2 (DENV2) (Protein Data Bank [PDB]: 5K5M).