. 2021 Jun 29;10(7):1621. doi: 10.3390/cells10071621

Table 1.

Comparison of the dominant peripheral blood NK (pNK) cell subset, decidual NK (dNK) cells, decidual-like tumor-infiltrating and tumor-associated NK (TINK, TANK, respectively) cells, in terms of the phenotype, angiogenic activity, and cytotoxicity.

NK Cell Subset	Phenotype	Proangiogenic Factors	Cytotoxicity
pNK cells	CD56^dimCD16^brightCD94⁺CD9⁻ CD49⁻ [9]	−	ADCC↑, perforin↑, granzymes↑, KIR↑, NKG2D↑, NCR↑ [78]
dNK cells	CD56^brightCD16⁻KIR⁺CD9⁺CD49⁺ [13,68]	HIF1↑, VEGF↑, IL-8↑, angiogenin↑, CXCL12↑, IFNɣ↑, MMP2↑, MMP9↑, TGFβ↑, TNF↑ [9,13,55,58]	degranulation capacity↓ NKp30↓, NKp44↓, NKp80↓, NKG2D↓ [59,79]
Decidual-like TINK cells non-small cell lung cancer (NSCLC) [8], renal cell carcinoma (RCC) [12], breast cancer [11,80], melanoma [11] colorectal cancer (CRC) [10,81] lung adenocarcinoma (pleural effusion) [82]	CD56^brightCD16^dim/− CD56+CD16⁻CD9⁺CD49⁺ CD56^brightCD16⁻CD49a⁺CD69⁺CD57^low	VEGFA↑, VEGFB↑, PlGF↑, HIF1↑, Ang2↑, IL-6↑, CCl3↑, CXCL1↑, CCR7↑, CD146R↑ IL-8↑ [8,10,12]	ADCC↓, perforin↓, NKp30↓, NKp44↓, NKp46↓, DNAM-1↓, NKG2A↑, NKG2D↓ CD107a↓ [10,54,81,82,83]
Decidual-like TANK cells prostate cancer [84] colorectal cancer [10]	CD56^brightCD9⁺CD49a⁺CXCR4⁺ CD56⁺CD16⁻CD9⁺CD49⁺	VEGF↑, angiogenin↑, MMP9↑, TIMP2↑, IL-8, ICAM-1↑, VCAM-1↑ [10,84]	degranulation capacity↓, NKG2D↓ [10,84]

ADCC: antibody-dependent cell mediated cytotoxicity; NCR: natural cytotoxicity receptor; VEGF: vascular endothelial growth factor; PlGF: placenta growth factor; Ang-2: angiopoietin 2; MMP: matrix metalloproteinase; TIMP: tissue inhibitor of metalloproteinase; ICAM-1: intercellular adhesion molecule 1; VCAM-1: vascular cell adhesion molecule 1.