Figure 5.

Expression levels of genes coding for the examined cytokines of endothelial cells (HBEC-5i) stimulated with plasma from three healthy control individual and four malaria patients. HBEC-5i cells were incubated for 7 h in the presence of 10% plasma derived from three control individuals and four malaria patients (Supplementary Tables S1, S3, S7 and S8). Subsequently, RNA was isolated from the HBEC-5i cells and a comparative transcriptome analysis was performed (Supplementary Table S9). VEGF*: Analysis excluding sample H8. M6, M9, M10, and M11: 4 biological replicates each; H5 and H10: 2 biological replicates each; H8: 1 biological replicate. Statistical analyses were performed using the Mann–Whitney U test (** p < 0.01; *** p < 0.001).