Table 1.
Sample ID | Gender | Age at Diagnosis | KPS | WHO Grade | Recurrent Tumor | OS (Months) | IDH1 R132H Mutation | ATRX Loss | p53 | MGMT Methylation | GTR | Therapy | Adjuvant Therapy | TTP (Months) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NB-00131/12 | M | 42 | 90 | IV | No | 13 | Negative | Not performed | Negative | No | No | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | / |
NB-00094/13 | M | 47 | 90 | IV | No | 16 | Negative | Not performed | Positive | Yes | Yes | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 10 |
17-H-21518 | M | 64 | 100 | IV | No | 16 | Negative | No | Negative | No | Yes | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 8 |
NB-00233/12 | F | 42 | 100 | IV | No | 18 | Negative | Not performed | Negative | No | Yes | 60 Gy radiotherapy + TMZ | No (TMZ side effects) | 6 |
NB-00464/12 | M | 62 | 90 | IV | No | 19 | Not performed | Not performed | Not performed | No | No | 30 Gy radiotherapy + TMZ | Adjuvant TMZ | 14 |
NB-00079/14 | M | 43 | 90 | IV | No | 20 | Positive | Not performed | Positive | No | Yes | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 15 |
17-H-05191 | M | 68 | 100 | IV | No | 21 | Negative | No | Positive | No | Yes | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 12 |
16-H-17976 | M | 66 | 70 | IV | No | 23 | Negative | No | Negative | Yes | Yes | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 16 |
NB-00173/14 | M | 55 | 90 | IV | No | 26 | Negative | Not performed | Negative | Yes | Yes | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 21 |
NB-00369/13 | F | 62 | 90 | IV | No | 31 | Negative | Not performed | Positive | No | Yes | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 26 |
NB-00450/12 | F | 58 | 80 | IV | No | 50 | Negative | Not performed | Negative | Yes | No | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 37 |
NB-00038/13 | F | 61 | 80 | IV | No | 58 | Negative | Not performed | Positive | No | Yes | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 14 |
NB-00339/13 | M | 22 | 100 | IV | No | 91 | Negative | Not performed | Negative | No | Yes | 60 Gy radiotherapy + TMZ | Adjuvant TMZ | 90 * |
NB-00046/12 | M | 62 | 80 | IV | No | 2 | Negative | Not performed | Negative | Yes | No | 34 Gy radiotherapy + TMZ | No | 2 |
NB-00003/15 | F | 68 | 70 | IV | No | 2 | Negative | Yes | Negative | No | No | 30 Gy radiotherapy | / | 2 |
17-H-31914 | M | 70 | 50 | IV | No | 2 | Negative | No | Negative | Yes | No | None | None | 2 |
KPS: Karnofsky performance scale; WHO: World Health Organization; IDH1: Isocitrate dehydrogenase 1; R: Arginine; H: Histidine; ATRX: ATP-dependent helicase ATRX, X-linked helicase II; p53: Tumor protein p53; MGMT: O6-methylguanine DNA methyltransferase promoter methylation status; GTR: Gross total resection; TTP: Time to progression; OS: overall survival; TMZ: Temozolomide; *: Patient presented with progression after the analysis was performed.