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Schematic representation of human PKD domain structure. The three members of the human PKD family of protein kinases (PKD1, PKD2, and PKD3) have a similar domain structure. The major domains and their functions are depicted here. P: putative insertion domain; ULD: ubiquitin-like domain; C1a and C1b: cysteine-rich zinc-finger regions a and b; PH: pleckstrin homology domain; PB: postsynaptic density-95/discs large/zonula occludens-1 (PDZ)-binding domain.
