Table 1.
Protein cargoes in TGN-to-PM transport carriers. The transport carriers considered here do not necessarily describe completely different export routes, because they share some machinery and cargoes (see text for details). However, since these transport carriers have been defined and characterized as such in the literature, we describe them separately here. TM: transmembrane protein; MA: membrane-associated protein; GPI-AP: glycosyl-phosphatidylinositol-anchored protein.
| Transport Carriers | Protein Name | Topology | Secretion Type | References |
|---|---|---|---|---|
| PKD-dependent carriers (General) | CD4 | TM | Constitutive | [25] |
| TGN46 | TM | Constitutive | [25] | |
| Furin | TM | Constitutive | [32] | |
| VSV-G (Basolateral PM) | TM | Constitutive | [25,26] | |
| ss-HRP | Soluble | Constitutive | [27] | |
| Insulin | Soluble | Regulated | [33,34] | |
| Chromogranin A | Soluble | Regulated | [35,36] | |
| ß1-integrin (Basolateral PM) | TM | Constitutive | [26] | |
| E-cadherin (Basolateral PM) | TM | Constitutive | [26] | |
| CtBP1/BARS-dependent carriers | VSV-G | TM | Constitutive | [37] |
| Low-density lipoprotein (LDL) receptor | TM | Constitutive | [38] | |
| Human growth hormone (hGH) | Soluble | Constitutive | [38] | |
| CARTS | TGN46 | TM | Constitutive | [39] |
| ss-HRP | Soluble | Constitutive | [39,40] | |
| PAUF | Soluble | Constitutive | [39] | |
| Lysozyme C | Soluble | Constitutive | [39] | |
| Synaptotagmin II | TM | Constitutive | [39] | |
| FM4-GPI (CD58) | GPI-AP | Constitutive | [41] | |
| EQ-SM (SM reporter protein) | MA | Constitutive | [41] | |
| SM-rich transport carriers | EQ-SM (SM reporter protein) | MA | Constitutive | [42] |
| FM4-GPI (CD58) | GPI-AP | Constitutive | [42] | |
| Cab45 | Soluble | Constitutive | [43,44,45] | |
| ss-HRP | Soluble | Constitutive | [44,46] | |
| Lysozyme C | Soluble | Constitutive | [45,47] | |
| Cartilage oligomeric matrix protein (COMP) | Soluble | Constitutive | [45,47] | |
| Lipoprotein lipase | MA | Constitutive | [48] | |
| Syndecan-1 | TM | Constitutive | [48] | |
| Rab6-positive carriers (General) | VSV-G | TM | Constitutive | [49,50] |
| Neuropeptide Y (NPY) | Soluble | Constitutive | [49,51] | |
| TNFα | Soluble | Constitutive | [52,53,54] | |
| Herpes Simplex virus 1 (HSV1) glycoproteins gD/gE | TM | Constitutive | [55] | |
| Collagen type X | Soluble | Constitutive | [53] | |
| CD59 | GPI-AP | Constitutive | [53] | |
| Placenta alkaline phosphatase (PLAP) | GPI-AP | Constitutive | [53] | |
| ß1-integrin | TM | Constitutive | [56] | |
| Membrane type 1-matrix metalloproteinase (MT1-MMP) | TM | Constitutive | [57] |