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. 2021 Jul 8;22(14):7330. doi: 10.3390/ijms22147330

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TI-12403 inhibits the growth of adenomatous polyposis coli (APC)-mutated colorectal cancer (CRC) cells. (A) COLO320DM and DLD-1 cells were treated with 10 μM TI-12403 and then incubated for 14 days. Colonies with more than 50 cells were counted. (B) Colony formation assay results presented as bar graphs showing the number of colonies. The bar graph represents the normalized values to control group. *** p < 0.001, ** p <0.01 compared to vehicle controls. (C) COLO320DM and DLD-1 cells were incubated with TI-12403 at the indicated concentrations. Cell viability was determined by MTT assay 72 h after treatment. ** p < 0.01, *** p < 0.001 compared to respective DMSO-treated cells.