Table 2.
Curcumin and donepezil mitigated levels of oxidative stress markers in the cerebellum and the hippocampus of treated BTBR mice.
| BTBR | ||||||||
|---|---|---|---|---|---|---|---|---|
| CUR | ||||||||
| C57 (SAL) | (SAL) | 25 mg/kg | 50 mg/kg | 100 mg/kg | 50 mg/kg + MLA (1 µg/kg) | MLA (1 µg/kg) | DOZ (1 mg/kg) | |
| SOD | ||||||||
| Cerebellum | 50.95 ± 1.89 | 36.42 ± 2.19 *** | 38.24 ± 2.05 | 36.16 ± 1.73 | 39.41 ± 3.04 | 36.91 ± 1.38 | 37.67 ± 1.26 | 36.52 ± 1.73 |
| Hippo-campus | 49.47 ± 1.52 | 37.70 ± 1.61 *** | 39.55 ± 1.67 | 49.36 ± 0.5 ## | 50.37 ± 1.55 ## | 48.61 ± 3.24 | 38.63 ± 1.45 | 36.95 ± 2.67 |
| CAT | ||||||||
| Cerebellum | 159.43 ± 6.92 | 127.95 ± 3.37 * | 128.30 ± 4.07 | 151.11 ± 5.47 # | 149.82 ± 4.72 # | 148.07 ± 5.10 # | 127.95 ± 3.37 | 133.95 ± 5.21 |
| Hippo-campus | 26.53 ± 4.90 | 106.58 ± 3.01 * | 104.13 ± 7.54 | 105.50 ± 3.77 | 108.11 ± 5.61 | 104.08 ± 3.97 | 103.38 ± 6.23 | 105.58 ± 3.12 |
Superoxide dismutase (SOD) and catalase (CAT) were assessed in two different brain parts of treated BTBR mice, namely the cerebellum and the hippocampus. BTBR mice showed a significant decrease in SOD and CAT compared to C57 mice. Effects of systemic administration of CUR (25, 50, and 100 mg/kg, i.p.) was assessed in C57 and BTBR mice. CUR (50 and 100 mg/kg, i.p.) significantly increased the reduced levels of SOD in the hippocampus, but failed to increase the decreased levels of SOD in the cerebellum of treated BTBR mice. CUR (50 and 100 mg/kg, i.p.) significantly increased the reduced levels of CAT in the cerebellum, but failed to increase the decreased levels of CAT in the hippocampus. *** p < 0.001 vs. C57 mice. # p < 0.05 vs. saline-treated BTBR mice. ## p < 0.05 vs. saline-treated BTBR mice. The effects of CUR were analyzed using two-way analysis of variance (ANOVA) with dose of drugs and animals (either BTBR or C57 mice) as the between-subjects factor, and post hoc comparisons were performed with Tukey’s test in case of a significant effect.