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. 2021 Jul 19;13(14):3606. doi: 10.3390/cancers13143606

Figure 3.

Figure 3

Dependency of bromodomain genes in systematic CRISPR knockout screens from the Cancer Dependency Map project (https://depmap.org/portal/depmap, accessed on 7 July 2021). The CERES score indicates the likelihood that a gene is essential [84]. A CERES score of 0 means the gene is not essential, while −1 is comparable to the median of all pan-essential genes. Data were retrieved from depmap.org (release 21Q1). (A) The percentage of cancer cell lines with CERES scores < −0.5 for each BRD gene across disease types. CERES scores for (B) BRD9, (C) SMARCA2, and (D) SP110 across disease types.