Figure 4.

A highly connected functional bromodomain protein-protein interaction (PPI) network. (A) Interaction network of bromodomain-containing proteins. The public PPI datasets contain curated PPI derived from a range of affinity purification approaches including affinity capture followed by mass spectrometry (MS), as well as proximity labelling and MS, yeast two-hybrid methods, and others [91]. Accordingly, all physical interactions for the 42 bromodomain-containing genes were processed and plotted with Cytoscape. Each of the bromodomain-containing proteins are displayed in a larger size, and are color coded by their respective functional group as indicated in the figure legend. (B) Interactions between different bromodomain-containing proteins. Interactions between 37 bromodomain proteins are depicted, as 5 bromodomain proteins do not interact with other bromodomain-containing proteins.