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. 2021 Jul 11;13(14):3470. doi: 10.3390/cancers13143470

Figure 4.

Figure 4

JQ1 + gemcitabine increases levels of DNA damage marker γH2AX and apoptosis marker cleaved caspase 3 in PDAC tumors in vivo. (A,D) FFPE sections from PA4 (A) and PA16 (D) tumor models were immunostained to detect the DNA damage marker γH2AX and the apoptosis marker cleaved caspase 3. Scale bar = 100 µm. (B,C,E,F) Quantitation of the γH2AX and cleaved caspase 3 (Cl. Caspase 3) results for PA4 (B,C) and PA16 (E,F) tumors are shown as bar graphs. Data are presented as the mean ± SEM and analyzed using one-way ANOVA (* P < 0.05, ** P < 0.01, *** P < 0.001).