Table 2.
Treatment related changes in microbiome and staphylococcal species in the two treatment groups 1.
| Dupilumab (n = 27) | Non-Targeted Treatment Group (n = 17) | |||||
|---|---|---|---|---|---|---|
| Significant Changes Following Treatment | ||||||
| NLS | LS | Nose | NLS | LS | Nose | |
| Shannon Diversity | - | +↑ | +↑* | - | - | - |
| Bacterial community structure | + | + | + | - | - | - |
| Bacterial genera | - | ↓Staphylococcus |
↑Rothia
↑Corynebacterium ↑Haemophilus ↑Veillonella |
- | - | - |
| staphylococcal species | ↓S. aureus ↑S. epidermidis ↑S. hominis ↑ S. saprophyticus |
↓S. aureus |
- | - | - | - |
1 Abbreviations: LS: lesional skin; NLS; nonlesional skin; +: significant change; -: no significant change; * not significant after adjusting for multiple testing; ↑: increase; ↓: decrease.