Figure 7.
(a) An evening chronotype associates with bipolar disorder. In addition to a valid association between chronotype and bipolar disorder, an intermediate association (p < 1 × 10−5) was found for ER+ breast cancer. (b) An evening chronotype associates with increased beer and cider consumption. There is a potential bi-directional relationship between increased alcohol intake and an evening chronotype both directly (blue lines) and mediated by lack of physical activity and elevated UBE2G2. Chronotype may influence the number of sexual partners, which may influence average alcohol intake (brown). There are numerous potential confounders relating body composition, loneliness, and diet.