Figure 5.

Most significant IPA canonical pathways recognised in the molecular profile of MS-High patients as compared to MS-Low patients. HMGB1 signalling and systemic lupus erythematosus in B cell signalling pathway exhibited a positive z-score, predicting an activation state; other CPs related to T and B cells (altered T cell and B cell signalling in rheumatoid arthritis, role of cytokines in mediating communication between immune cells, T helper cell differentiation and communication between innate and adaptive immune cells) were significantly annotated, without an activation score. Furthermore, other CPs with a significant z-score were PD-1 PD1-L cancer immunotherapy pathway, IL-17 signalling and neuroinflammation signalling pathway. For the complete list of CPs of MS-High profile see Supplementary Table S3.