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. 2021 Jul 14;9(7):1509. doi: 10.3390/microorganisms9071509

Table A6.

Full list of KEGG pathways identified in the STRING analysis of the ERVK integrase interactome.

KEGG Term ID Term Description Observed Gene Count Background Gene Count Strength False Discovery Rate
hsa04218 Cellular senescence 28 156 1.27 2.30 × 10−23
hsa05203 Viral carcinogenesis 29 183 1.21 3.47 × 10−23
hsa04110 Cell cycle 25 123 1.32 2.38 × 10−22
hsa04114 Oocyte meiosis 23 116 1.31 2.13 × 10−20
hsa05169 Epstein–Barr virus infection 24 194 1.11 4.01 × 10−17
hsa05205 Proteoglycans in cancer 23 195 1.08 4.79 × 10−16
hsa04650 Natural killer cell-mediated cytotoxicity 19 124 1.2 3.96 × 10−15
hsa04068 FoxO signaling pathway 19 130 1.18 7.58 × 10−15
hsa04750 Inflammatory mediator regulation of TRP channels 17 92 1.28 8.12 × 10−15
hsa05167 Kaposi’s sarcoma-associated herpesvirus infection 21 183 1.07 1.30 × 10−14
hsa04720 Long-term potentiation 15 64 1.38 1.77 × 10−14
hsa05161 Hepatitis B 19 142 1.14 2.19 × 10−14
hsa05206 MicroRNAs in cancer 19 149 1.12 4.49 × 10−14
hsa04370 VEGF signaling pathway 14 59 1.39 1.11 × 10−13
hsa04660 T cell receptor signaling pathway 16 99 1.22 2.39 × 10−13
hsa04012 ErbB signaling pathway 15 83 1.27 3.37 × 10−13
hsa04611 Platelet activation 17 123 1.15 3.37 × 10−13
hsa04921 Oxytocin signaling pathway 18 149 1.09 4.19 × 10−13
hsa04115 p53 signaling pathway 14 68 1.33 4.53 × 10−13
hsa05200 Pathways in cancer 29 515 0.76 6.20 × 10−13
hsa05166 HTLV-I infection 21 250 0.94 1.82 × 10−12
hsa04933 AGE-RAGE signaling pathway in diabetic complications 15 98 1.2 2.24 × 10−12
hsa04510 Focal adhesion 19 197 1 2.57 × 10−12
hsa04659 Th17 cell differentiation 15 102 1.18 3.46 × 10−12
hsa05031 Amphetamine addiction 13 65 1.31 3.95 × 10−12
hsa04728 Dopaminergic synapse 16 128 1.11 4.97 × 10−12
hsa04658 Th1 and Th2 cell differentiation 14 88 1.21 7.29 × 10−12
hsa05165 Human papillomavirus infection 22 317 0.85 1.27 × 10−11
hsa04914 Progesterone-mediated oocyte maturation 14 94 1.19 1.52 × 10−11
hsa04310 Wnt signaling pathway 16 143 1.06 2.02 × 10−11
hsa04390 Hippo signaling pathway 16 152 1.04 4.56 × 10−11
hsa04062 Chemokine signaling pathway 17 181 0.99 5.10 × 10−11
hsa04917 Prolactin signaling pathway 12 69 1.25 1.03 × 10−10
hsa04662 B cell receptor signaling pathway 12 71 1.24 1.35 × 10−10
hsa04919 Thyroid hormone signaling pathway 14 115 1.1 1.47 × 10−10
hsa04064 NF-kappa B signaling pathway 13 93 1.16 1.57 × 10−10
hsa04270 Vascular smooth muscle contraction 14 119 1.08 2.11 × 10−10
hsa04360 Axon guidance 16 173 0.98 2.24 × 10−10
hsa05162 Measles 14 133 1.04 7.76 × 10−10
hsa05223 Non-small cell lung cancer 11 66 1.23 9.08 × 10−10
hsa04666 Fc gamma R-mediated phagocytosis 12 89 1.14 1.18 × 10−9
hsa04380 Osteoclast differentiation 13 124 1.03 3.48 × 10−9
hsa01521 EGFR tyrosine kinase inhibitor resistance 11 78 1.16 4.18 × 10−9
hsa04010 MAPK signaling pathway 18 293 0.8 5.87 × 10−9
hsa04931 Insulin resistance 12 107 1.06 7.37 × 10−9
hsa04910 Insulin signaling pathway 13 134 1 7.61 × 10−9
hsa04724 Glutamatergic synapse 12 112 1.04 1.14 × 10−8
hsa04151 PI3K-Akt signaling pathway 19 348 0.75 1.17 × 10−8
hsa04912 GnRH signaling pathway 11 88 1.11 1.17 × 10−8
hsa04664 Fc epsilon RI signaling pathway 10 67 1.19 1.30 × 10−8
hsa04071 Sphingolipid signaling pathway 12 116 1.03 1.51 × 10−8
hsa04722 Neurotrophin signaling pathway 12 116 1.03 1.51 × 10−8
hsa01522 Endocrine resistance 11 95 1.08 2.24 × 10−8
hsa04014 Ras signaling pathway 15 228 0.83 5.08 × 10−8
hsa04210 Apoptosis 12 135 0.96 6.74 × 10−8
hsa05152 Tuberculosis 13 172 0.89 1.01 × 10−7
hsa04540 Gap junction 10 87 1.07 1.11 × 10−7
hsa05221 Acute myeloid leukemia 9 66 1.15 1.42 × 10−7
hsa05214 Glioma 9 68 1.13 1.74 × 10−7
hsa05222 Small cell lung cancer 10 92 1.05 1.74 × 10−7
hsa01524 Platinum drug resistance 9 70 1.12 2.13 × 10−7
hsa04215 Apoptosis—multiple species 7 31 1.37 2.13 × 10−7
hsa04926 Relaxin signaling pathway 11 130 0.94 3.72 × 10−7
hsa04015 Rap1 signaling pathway 13 203 0.82 5.46 × 10−7
hsa04960 Aldosterone-regulated sodium reabsorption 7 37 1.29 5.77 × 10−7
hsa04668 TNF signaling pathway 10 108 0.98 6.23 × 10−7
hsa04261 Adrenergic signaling in cardiomyocytes 11 139 0.91 6.58 × 10−7
hsa05145 Toxoplasmosis 10 109 0.98 6.58 × 10−7
hsa04725 Cholinergic synapse 10 111 0.97 7.54 × 10−7
hsa05120 Epithelial cell signaling in Helicobacter pylori infection 8 66 1.1 1.53 × 10−6
hsa04340 Hedgehog signaling pathway 7 46 1.2 1.97 × 10−6
hsa04961 Endocrine and other factor-regulated calcium reabsorption 7 47 1.19 2.22 × 10−6
hsa04066 HIF-1 signaling pathway 9 98 0.98 2.44 × 10−6
hsa04520 Adherens junction 8 71 1.06 2.44 × 10−6
hsa04916 Melanogenesis 9 98 0.98 2.44 × 10−6
hsa05225 Hepatocellular carcinoma 11 163 0.84 2.56 × 10−6
hsa04621 NOD-like receptor signaling pathway 11 166 0.83 2.99 × 10−6
hsa05014 Amyotrophic lateral sclerosis (ALS) 7 50 1.16 2.99 × 10−6
hsa05220 Chronic myeloid leukemia 8 76 1.04 3.62 × 10−6
hsa05020 Prion diseases 6 33 1.27 4.44 × 10−6
hsa04020 Calcium signaling pathway 11 179 0.8 5.69 × 10−6
hsa04670 Leukocyte transendothelial migration 9 112 0.92 6.16 × 10−6
hsa04726 Serotonergic synapse 9 112 0.92 6.16 × 10−6
hsa04723 Retrograde endocannabinoid signaling 10 148 0.84 7.20 × 10−6
hsa04727 GABAergic synapse 8 88 0.97 9.28 × 10−6
hsa04934 Cushing’s syndrome 10 153 0.83 9.30 × 10−6
hsa04924 Renin secretion 7 63 1.06 1.09 × 10−5
hsa04024 cAMP signaling pathway 11 195 0.76 1.14 × 10−5
hsa04657 IL-17 signaling pathway 8 92 0.95 1.20 × 10−5
hsa04022 cGMP-PKG signaling pathway 10 160 0.81 1.28 × 10−5
hsa04140 Autophagy—animal 9 125 0.87 1.28 × 10−5
hsa04630 Jak-STAT signaling pathway 10 160 0.81 1.28 × 10−5
hsa04713 Circadian entrainment 8 93 0.95 1.28 × 10−5
hsa05146 Amoebiasis 8 94 0.94 1.32 × 10−5
hsa05215 Prostate cancer 8 97 0.93 1.62 × 10−5
hsa05231 Choline metabolism in cancer 8 98 0.92 1.72 × 10−5
hsa04371 Apelin signaling pathway 9 133 0.84 1.94 × 10−5
hsa04930 Type II diabetes mellitus 6 46 1.13 2.04 × 10−5
hsa03450 Non-homologous end-joining 4 13 1.5 3.50 × 10−5
hsa04072 Phospholipase D signaling pathway 9 145 0.81 3.61 × 10−5
hsa05226 Gastric cancer 9 147 0.8 3.96 × 10−5
hsa05210 Colorectal cancer 7 85 0.93 5.70 × 10−5
hsa04217 Necroptosis 9 155 0.78 5.77 × 10−5
hsa04730 Long-term depression 6 60 1.01 7.67 × 10−5
hsa04925 Aldosterone synthesis and secretion 7 93 0.89 9.48 × 10−5
hsa04530 Tight junction 9 167 0.74 9.70 × 10−5
hsa05131 Shigellosis 6 63 0.99 9.70 × 10−5
hsa05010 Alzheimer’s disease 9 168 0.74 9.98 × 10−5
hsa05164 Influenza A 9 168 0.74 9.98 × 10−5
hsa05160 Hepatitis C 8 131 0.8 0.00011
hsa03440 Homologous recombination 5 40 1.11 0.00012
hsa04922 Glucagon signaling pathway 7 100 0.86 0.00014
hsa05140 Leishmaniasis 6 70 0.95 0.00016
hsa05168 Herpes simplex infection 9 181 0.71 0.00016
hsa04971 Gastric acid secretion 6 72 0.93 0.00018
hsa04918 Thyroid hormone synthesis 6 73 0.93 0.00019
hsa05133 Pertussis 6 74 0.92 0.0002
hsa05212 Pancreatic cancer 6 74 0.92 0.0002
hsa05224 Breast cancer 8 147 0.75 0.00021
hsa04150 mTOR signaling pathway 8 148 0.75 0.00022
hsa05110 Vibrio cholerae infection 5 48 1.03 0.00025
hsa04810 Regulation of actin cytoskeleton 9 205 0.66 0.00037
hsa04911 Insulin secretion 6 84 0.87 0.00037
hsa05130 Pathogenic Escherichia coli infection 5 53 0.99 0.00037
hsa04970 Salivary secretion 6 86 0.86 0.00041
hsa05416 Viral myocarditis 5 56 0.96 0.00046
hsa05032 Morphine addiction 6 91 0.83 0.00053
hsa05213 Endometrial cancer 5 58 0.95 0.00053
hsa04915 Estrogen signaling pathway 7 133 0.73 0.00063
hsa05418 Fluid shear stress and atherosclerosis 7 133 0.73 0.00063
hsa04213 Longevity regulating pathway—multiple species 5 61 0.93 0.00064
hsa04550 Signaling pathways regulating pluripotency of stem cells 7 138 0.72 0.00076
hsa05211 Renal cell carcinoma 5 68 0.88 0.001
hsa04920 Adipocytokine signaling pathway 5 69 0.87 0.0011
hsa05219 Bladder cancer 4 41 1 0.0013
hsa04211 Longevity regulating pathway 5 88 0.77 0.0029
hsa04923 Regulation of lipolysis in adipocytes 4 53 0.89 0.0031
hsa04120 Ubiquitin mediated proteolysis 6 134 0.66 0.0033
hsa04070 Phosphatidylinositol signaling system 5 97 0.72 0.0043
hsa05034 Alcoholism 6 142 0.64 0.0043
hsa05142 Chagas disease (American trypanosomiasis) 5 101 0.71 0.005
hsa04620 Toll-like receptor signaling pathway 5 102 0.7 0.0051
hsa04932 Non-alcoholic fatty liver disease (NAFLD) 6 149 0.62 0.0053
hsa05230 Central carbon metabolism in cancer 4 65 0.8 0.0059
hsa03410 Base excision repair 3 33 0.97 0.0066
hsa05143 African trypanosomiasis 3 34 0.96 0.0071
hsa04622 RIG-I-like receptor signaling pathway 4 70 0.77 0.0075
hsa05218 Melanoma 4 72 0.76 0.0081
hsa05216 Thyroid cancer 3 37 0.92 0.0087
hsa05202 Transcriptional misregulation in cancer 6 169 0.56 0.0091
hsa04152 AMPK signaling pathway 5 120 0.63 0.0093
hsa04962 Vasopressin-regulated water reabsorption 3 44 0.85 0.0132
hsa05132 Salmonella infection 4 84 0.69 0.0132
hsa03015 mRNA surveillance pathway 4 89 0.67 0.0157
hsa04913 Ovarian steroidogenesis 3 49 0.8 0.0171
hsa05030 Cocaine addiction 3 49 0.8 0.0171
hsa03460 Fanconi anemia pathway 3 51 0.78 0.0187
hsa05134 Legionellosis 3 54 0.76 0.0215
hsa04137 Mitophagy—animal 3 63 0.69 0.0314
hsa04714 Thermogenesis 6 228 0.43 0.0314
hsa04927 Cortisol synthesis and secretion 3 63 0.69 0.0314
hsa04976 Bile secretion 3 71 0.64 0.0413
hsa04136 Autophagy—other 2 30 0.84 0.045