Table 2.
Multivariate analysis of potential predictors of overall survival and disease-free survival using Cox proportional hazards models.
| Variables | Overall Survival | Disease-Free Survival | ||||
|---|---|---|---|---|---|---|
| p | HR | 95% CI | p | HR | 95% CI | |
| Eg5 low (vs. high) | <0.001 | 0.377 | 0.214–0.665 | <0.001 | 0.334 | 0.187–0.596 |
| Eg5 medium (vs. high) | 0.391 | 0.793 | 0.468–1.346 | 0.352 | 0.773 | 0.449–1.330 |
| Age | 0.133 | 1.014 | 0.996–1.033 | 0.594 | 1.005 | 0.988–1.022 |
| Male (vs. female) | 0.924 | 0.971 | 0.537–1.759 | 0.286 | 0.732 | 0.412–1.299 |
| HBsAg positive | 0.007 | 2.580 | 1.302–5.112 | 0.065 | 1.880 | 0.961–3.675 |
| Anti-HCV positive | 0.063 | 1.761 | 0.969–3.201 | 0.188 | 1.498 | 0.821–2.733 |
| AJCC stage I (vs. III) | <0.001 | 0.314 | 0.184–0.538 | 0.004 | 0.464 | 0.274–0.784 |
| AJCC stage II (vs. III) | <0.001 | 0.305 | 0.168–0.552 | <0.001 | 0.372 | 0.209–0.663 |
| AFP > 400 ng/mL | 0.486 | 1.185 | 0.735–1.911 | 0.056 | 1.599 | 0.988–2.589 |
| Child B (vs. A) | 0.355 | 1.458 | 0.656–3.237 | 0.306 | 1.531 | 0.677–3.460 |
Abbreviations: OS = overall survival; DFS = disease-free survival; HR = hazard ratio; CI = confidence interval; HBsAg = hepatitis B virus surface antigen; HCV = hepatitis C virus; AJCC = American Joint Committee on Cancer; AFP = α-fetoprotein.