Table 1.

Minimum inhibitory concentration (MIC) of peptidomimetics against S. aureus, E. coli and P. aeruginosa and the calculated AlogP values of peptidomimetics.

	Compound	AlogP	MIC (μM/μg/mL)
			S. aureus	E. coli	P. aeruginosa
Glyoxamide derivatives	10a	2.61	250/106 [50]	ND	ND
	10b	3.38	94/47 [50]	ND	ND
	10c	4.26	24/12 [51]	ND	ND
	10d	5.91	8/4.6	ND	ND
	11a	4.39	32/15	ND	ND
	11b	5.16	32/18	ND	ND
	11c	6.04	16/8.9	ND	ND
	11d	7.69	250/158	ND	ND
	12a	6.17	63/34	ND	ND
	12b	6.94	250/154	ND	ND
	12c	7.82	>250/>153	ND	ND
	21	5.91	16/9.2	ND	ND
Tertiary ammonium chloride salts	13a	−0.89	>250/>116 [50]	ND	ND
	13b	−0.12	63/34 [50]	ND	ND
	13c	0.76	16/8.6 [51]	ND	ND
	13d	2.41	16/9.8	ND	ND
	14a	0.89	16/8.3	ND	ND
	14b	1.66	16/9.6	ND	ND
	14c	2.54	16/9.5	ND	ND
	14d	4.18	125/84	ND	ND
	15a	2.67	63/36	ND	ND
	15b	3.44	250/163	ND	ND
	15c	4.32	>250/>163	ND	ND
	22	2.41	16/9.8	ND	ND
Quaternary ammonium iodide salts	16a	−1.55	250/142 [50]	ND	ND
	16b	−0.78	63/41 [50]	ND	ND
	2, 16c	0.10	16/10 [51]	32/21 [51]	125/80 [51]
	16d	1.75	4/2.9	>250/>180	>250/>180
	17a	0.23	16/10	ND	ND
	17b	1.00	8/5.6	32/22	>250/>176
	17c	1.88	8/5.6	32/22	>250/>175
	17d	3.52	63/48	ND	ND
	18a	2.01	8/5.4	>250	>250
	18b	2.78	125/95	ND	ND
	18c	3.65	250/189	ND	ND
	23	1.75	8/5.8	ND	ND
Guanidinium hydrochloride salts	33a	−1.46	47/22 [50]	ND	ND
	1, 33b	−0.69	12/6.7 [50]	ND	ND
	33c	0.19	8/4.4 [51]	63/35 [51]	63/35 [51]
	33d	1.84	16/10	ND	ND
	34a	0.32	8/4.3	16/8.5	>250/>133
	34b	1.09	16/9.8	>250/>153	>250/>153
	34c	1.97	32/19	ND	ND
	35a	2.10	250/147	ND	ND
	35b	2.87	>250/>167	ND	ND
	35c	3.75	>250/>166	ND	ND

ND = Not determined.