Table 2.

IC₅₀ value of peptidomimetics against MRC-5 normal human lung fibroblasts and their therapeutic indices with respect to S. aureus and E. coli.

	Compound	IC50 (μM/μg/mL)	Therapeutic Index
			S. aureus	E. coli
Glyoxamide derivatives	10d	3.48/2.01	0.44	N/A
Tertiary ammonium chloride salts	13d	3.76/2.31	0.24	N/A
	22	3.46/2.13	0.22	N/A
Quaternary ammonium iodide salts	16d	53.7/38.6	15.4	N/A
	17b	18.3/12.9	2.29	0.57
	17c	57.5/40.2	7.18	1.80
	18a	52.4/35.6	6.54	N/A
	23	15.4/11.1	1.93	N/A
Guanidinium hydrochloride salts	33d	16.9/10.6	1.05	N/A
	34a	27.2/14.5	3.40	1.70
	34b	21.1/14.8	1.32	N/A
Positive control	TY-01	14.2/7.83	N/A	N/A

N/A = Not applicable.