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. 2021 Jul 7;22(14):7294. doi: 10.3390/ijms22147294

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic overview of in vivo data regarding extracellular vesicles in the brain and neuromuscular junction. (A) Overview of EV-related communication in the Central Nervous System (CNS). In vivo data has shown that neuron-derived EVs are taken up by astrocytes, changing protein expression in these cells. Oligodendrocyte-derived EVs have been linked to myelination of axons. CNP: 2′,3′-cyclic nucleotide 3′-phosphodiesterase, GLT1: glutamate transporter 1, PLP: proteolipid protein. (B) The role of EVs in signaling at the neuromuscular junction. EVi: Evenness Interrupted, EVs: extracellular vesicles, GLT1: glutamate transporter 1, Wnt: Wingless-related integration site.