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. 2021 Jul 10;22(14):7417. doi: 10.3390/ijms22147417

Table 1.

Dietary regimens. Table showing the experimental method (type of nerve injury and animal model) and the different dietary regimens.

Reference Type of Nerve Lesion and Animal Model Description and Timing of the Diet
Ketogenic Diet
Li et al., 2020 [22] Sciatic nerve crush
(Sprague–Dawley rats)
65.8% fat, 3.0% carbohydrate, and 18.1% protein for 8 weeks after injury
Mayr et al., 2020 [23] Transection of the common peroneal and tibial nerves in mouse
(C57/BL6 mice)
75.1% fat, 3.2% carbohydrates, and 8.6% protein for 7 days before injury and up to 28 day after injury
Liśkiewicz et al., 2016 [24] Sciatic nerve crush
(Wistar rats)
79% fat, 0.8% carbohydrates, and 9.5% protein for 6 weeks after injury. Preconditioned group received KD also for 3 weeks before injury
Caloric restriction
De Angelis et al., 2020 [25] Chronic constriction injury of sciatic nerve in mouse
(CD1 male mice 12 months old)
40% less of daily consumption for 7 days after CCI
Coccurello et al., 2018 [26] Chronic constriction injury (CCI) of sciatic nerve
(Wild-type CD1 male mice, Ambra1+ transgenic CD1 male mice)
40% less of daily consumption for 7 days after CCI
High-fat diet
Song et al., 2018 [27] Plantar incision
(Long-Evans rats)
40% fat administrated with different timing: a group received a high-fat diet for 6 weeks before injury and 2 weeks after, another group was fed with high-fat diet for 7 weeks and then switched back to standard diet for 2 weeks before to plantar incision, while in the last group, only male rats were switched to high-fat diet 1 week before injury
Bekar et al., 2014 [28] Sciatic nerve crush injury
(Sprague–Dawley rats)
40% fat for 3 months (started before injury and ended 4 weeks after injury)