Table 2.
PUFAS. Table showing the experimental method (type of nerve injury and animal model) and the dose and method of administration of the PUFAS.
| Reference | Type of Nerve Lesion and Animal Model | Type and Timing of Administration/Experimental Groups |
|---|---|---|
| Omega-3 | ||
| Oktay et al., 2020 [53] | Sciatic nerve crush (Sprague–Dawley male rat) |
50 or 100 mg/kg intraperitoneal alpha-lipoic acid (ALA) injection was done daily after nerve injury for 14 days |
| Unda et al., 2020 [51] | Sciatic nerve chronic constriction injury (Wistar rats) |
Saline solution with concentrated salmon oil ω-3 (0.72 g/kg) administered orally for 21 consecutive days |
| Silva et al., 2017 [54] | Partial sciatic nerve ligation model (Swiss mice) |
DHA/EPA-concentrate fish oil 2.3 g/kg orally administered 5 days/week for 2 weeks after nerve injury |
| Demir et al., 2014 [55] | Sciatic nerve crush (adult female albino Wistar rats) |
ALA was suspended in distilled water 1 mL (per rat and administered orally at a dosage of 25 or 50 mg/kg by gavage), daily for 30 days |
| Senoglu et al., 2009 [56] | Sciatic nerve crush (female Sprague–Dawley rats) |
100 mg/kg intraperitoneal ALA injection was done 24 and 1 h before crush injury |
| Omega-6 | ||
| Ramli et al., 2017 [57] | Sciatic nerve crush injury (Sprague–Dawley rats) |
6000 mg/day of evening primrose oil through an esophageal feeding tube starting from day 1 after nerve crush for 4 weeks |