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AMPK activation ameliorates the senescence in heart and hippocampus. Representative images from immunoblot against p53, p21 and GAPDH from heart (A–C) and hippocampus (F–H) tissues. The representative images from immunoblot against AMPK, p-AMPK and GAPDH from heart (D,E) and hippocampus (I,J) tissues. The expression levels of proteins were quantified using Images J software. All data are represented as mean ± SD (n = 3–4) * p < 0.05; ** p < 0.01; *** p < 0.001 and **** p < 0.0001.
