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A delicate balance of the NOS/arginase activities in the human sinonasal system modifies the bioavailability of the NOS substrate based on CRS phenotypes. CRS: chronic rhinosinusitis; ECRS: eosinophilic chronic rhinosinusitis; NO: nitric oxide; NOS: nitric oxide synthase; ONOO−: peroxynitrite; O2: superoxide.
