Table 1.
Characteristics of a series of 96 giant pituitary adenomas.
| Demographics | N. | % |
|---|---|---|
| Male | 55 | 57.3 |
| Female | 41 | 42.7 |
| Mean Age (years) | 52.2 (26–81) | |
| Mean tumor diameter (mm) | 46.5 (41–61) | |
| KNOSP Classification | ||
| Grade 0 | 30 | 31.2 |
| Grade 1 | 24 | 25.0 |
| Grade 2 | 19 | 19.8 |
| Grade 3 | 9 | 9.4 |
| Grade 4 | 14 | 14.6 |
| Endocrinological status | ||
| Non-functioning | 96 | 100 |
| Preoperative Clinical symptoms and signs | ||
| Visual field defects | 78 | 81.2 |
| Anterior pituitary insufficiency | 53 | 55.2 |
| Headache | 12 | 12.5 |
| Visual acuity deficit | 9 | 9.4 |
| Drowsiness | 3 | 3.1 |
| Treatment | ||
| EEA-TTP 1 | 96 | 100 |
| GPA consistency | ||
| Soft | 50 | 52.1 |
| Firm/fibrous | 46 | 47.9 |
| GPA vascularization | ||
| Significant | 31 | 32.3 |
| Not significant | 65 | 67.7 |
| Extent of resection | ||
| GTR 2 (100%) | 34 | 35.4 |
| NTR 3 (96 to 99%) | 12 | 12.5 |
| STR 4 (75 to 95%) | 50 | 52.1 |
| Clinical outcome | ||
| Visual improvement | 77 | 98.7 |
| Recovery of pituitary function | 27 | 50.9 |
| Surgical complications | ||
| CSF 5 leak | 7 | 7.3 |
| Meningitis | 7 | 7.3 |
| Apoplexy of residual tumor | 2 | 2.1 |
| Hydrocephalus | 1 | 1.0 |
| Right eye Blindness | 1 | 1.0 |
| Transient DI | 37 | 37.5 |
| Transient delayed hyponatremia | 20 | 20.8 |
| Progression | ||
| Yes | 16 | 16.7 |
| No | 80 | 83.3 |
| Treatment of 16 recurrences | ||
| Re-do EEA-TTP | 3 | 3.1 |
| GKRS 6 | 4 | 4.2 |
| SRT 7 | 9 | 9.4 |
1 EEA-TTP, extended endoscopic approach transtuberculum/transplanum. 2 GTR, gross total removal. 3 NTR, near total removal. 4 STR, subtotal removal. 5 CSF, cerebrospinal fluid. 6 GKRS, gamma-knife radiosurgery. 7 SRT, stereotactic radiotherapy.