Table 3.
Pathway enrichment analysis (BioPlanet) of differentially regulated genes (DRGs) between pericytes cultured with and without endothelial cells (ECs).
| Pathway | Overlap | Adj. p-Value |
|---|---|---|
| TGF-beta regulation of extracellular matrix | 132/565 | 1.09 × 10−11 |
| Epidermal growth factor receptor 1 (EGFR1) pathway | 45/152 | 2.32 × 10−6 |
| Brain-derived neurotrophic factor (BDNF) signaling pathway | 63/261 | 8.33 × 10−6 |
| T cell receptor regulation of apoptosis | 118/603 | 8.33 × 10−6 |
| Follicle-stimulating hormone (FSH) regulation of apoptosis | 63/263 | 8.77 × 10−6 |
| Messenger RNA processing | 52/203 | 1.14 × 10−5 |
| Interleukin-1 regulation of extracellular matrix | 36/120 | 1.64 × 10−5 |
| Interferon alpha/beta signaling | 24/64 | 2.03 × 10−5 |
| Smooth muscle contraction | 13/22 | 2.41 × 10−5 |
| Interferon signaling | 44/168 | 3.61 × 10−5 |
| Interleukin-2 signaling pathway | 149/847 | 5.46 × 10−5 |
| Ataxia telangiectasia mutated (ATM) pathway | 19/48 | 1.05 × 10−4 |
| Interleukin-4 regulation of apoptosis | 58/267 | 3.54 × 10−4 |
| Lipid metabolism regulation by peroxisome proliferator-activated receptor alpha (PPAR-alpha) | 31/112 | 4.19 × 10−4 |
| Lipid and lipoprotein metabolism | 92/489 | 4.28 × 10−4 |
| Fatty acid, triacylglycerol, and ketone body metabolism | 41/173 | 8.60 × 10−4 |
| Activator protein 1 (AP-1) transcription factor network | 22/70 | 9.30 × 10−4 |
| Integrated breast cancer pathway | 37/152 | 1.07 × 10−3 |
| Retinoic acid receptor-mediated signaling | 13/30 | 1.09 × 10−3 |
| Gene expression | 158/968 | 1.17 × 10−3 |
| Angiogenesis | 11/23 | 1.34 × 10−3 |
| Senescence and autophagy | 27/99 | 1.34 × 10−3 |
| Uridine diphosphate (UDP)-N-acetyl-glucosamine biosynthesis | 5/5 | 1.34 × 10−3 |
| Capped intron-containing pre-mRNA processing | 34/138 | 1.34 × 10−3 |
| Type II interferon signaling (interferon-gamma) | 17/50 | 1.91 × 10−3 |
Pathway enrichment analysis of differentially regulated genes (DRGs) between pericytes cultured with and without endothelial cells. Analysis was performed using NCATS BioPlanet on the Enrichr website by uploading DRGs as determined by the Transcriptome Analysis Console (TAC). Second column describes number of regulated genes compared to total number of genes in the pathway, and p-values adjusted for multiple testing are denoted in the last column. The 25 most significant pathways are listed.