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Frequency of APC inactivation in different human cancer types. Genomic tumor analyses show that APC is one of the most frequently inactivated tumor suppressor genes across all solid tumor types [116,117]. While inactivation of APC in FAP and sporadic CRCs is due to APC mutation, in other cancers, APC inactivation often results from hyper-methylation of APC’s promoter and its epigenetic silencing.
