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. 2021 Jun 23;10(7):1582. doi: 10.3390/cells10071582

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Segregation of the heterochromatin (HR) compartment in SV-40 transformed hamster fibroblast cell line 4/21: (a) the undifferentiated growth state; (b) after 2 min with bleomycin (01%/HBSS)—the pattern of HR nucleation; (c) 20 min bleomycin treatment—no compartmentation after deep chromatin fragmentation; (d) 1% DMSO 5-day-induced typical differentiation pattern of HR distribution in cell nuclei of the same cell line; (a–d) republished from [53].

Segregation of the heterochromatin (HR) compartment in SV-40 transformed hamster fibroblast cell line 4/21: (a) the undifferentiated growth state; (b) after 2 min with bleomycin (01%/HBSS)—the pattern of HR nucleation; (c) 20 min bleomycin treatment—no compartmentation after deep chromatin fragmentation; (d) 1% DMSO 5-day-induced typical differentiation pattern of HR distribution in cell nuclei of the same cell line; (a–d) republished from [53].