Table 1.
Proteomic identification of sarcomere-associated proteins and related isoforms in mouse extraocular muscle.
| Accession | Protein | Gene | Score | Coverage % |
Peptides | Molecular Mass (kDa) |
|---|---|---|---|---|---|---|
| E9Q8K5 | Titin, muscle- specific |
TTN | 171.5 | 2.14 | 52 | 3713.7 |
| Q5SX40 | Myosin-1 heavy chain, MyHC-IId, fast muscle | MYH1 | 459.6 | 31.10 | 63 | 223.2 |
| G3UW82 | Myosin-2 heavy chain, MyHC-IIa, fast muscle | MYH2 | 382.7 | 31.15 | 60 | 223.1 |
| P13541 | Myosin-3 heavy chain, MyHC-embryonic, muscle | MYH3 | 125.1 | 11.70 | 24 | 223.7 |
| Q5SX39 | Myosin-4, MyHC-IIb, fast muscle | MYH4 | 472.9 | 32.75 | 68 | 222.7 |
| Q91Z83 | Myosin-7 heavy chain, MyHC-I, slow muscle | MYH7 | 96.04 | 10.70 | 20 | 222.7 |
| P13542 | Myosin-8 heavy chain, MyHC-perinatal, muscle | MYH8 | 277.9 | 24.68 | 47 | 222.6 |
| Q8VDD5 | Myosin-9 heavy chain, MyHC-cellular, type A | MYH9 | 87.81 | 10.61 | 20 | 226.2 |
| Q61879 | Myosin-10 heavy chain, MyHC-cellular, type B | MYH10 | 20.79 | 2.68 | 5 | 228.8 |
| A0A2R8VHF9 | Myosin-11 heavy chain, smooth muscle | MYH11 | 255.1 | 20.07 | 44 | 223.2 |
| B1AR69 | Myosin-13 heavy chain, extraocular muscle | MYH13 | 217.41 | 17.03 | 31 | 223.4 |
| K3W4R2 | Myosin-14 heavy chain, MyHC-eom, developmental | MYH14 | 25.40 | 3.45 | 6 | 228.4 |
| E9Q264 | Myosin-15 heavy chain, extraocular muscle | MYH15 | 10.20 | 1.56 | 3 | 221.7 |
| P05977 | Myosin light chain MLC-1/3, muscle | MYL1 | 74.36 | 45.21 | 8 | 20.6 |
| A0A0U1RP93 | Myosin light chain MLC-2, muscle | MYLPF | 28.02 | 10.07 | 1 | 16.9 |
| Q60605 | Myosin light chain MLC-3, muscle | MYL6 | 56.91 | 54.30 | 7 | 16.9 |
| D3YU50 | Myosin-binding protein C, slow |
MYBPC1 | 20.96 | 5.24 | 4 | 126.5 |
| A0A571BF46 | Nebulin | NEB | 15.55 | 1.32 | 8 | 866.5 |
| P68033 | Actin, alpha, skeletal muscle |
ACTC1 | 382.05 | 66.84 | 26 | 42.0 |
| P60710 | Actin, beta, cytoplasmic | ACTB | 384.11 | 52.53 | 25 | 41.7 |
| E9Q452 | Tropomyosin alpha-1 |
TPM1 | 119.92 | 40.93 | 14 | 32.5 |
| A2AIM4 | Tropomyosin beta | TPM2 | 112.31 | 41.55 | 16 | 33.0 |
| D3Z6I8 | Tropomyosin alpha-3 |
TPM3 | 47.89 | 43.72 | 12 | 28.7 |
| A0A571BEU1 | Tropomyosin alpha-4 |
TPM4 | 4.33 | 14.56 | 3 | 18.4 |
| P20801 | Troponin C, muscle | TNNC2 | 3.99 | 11.88 | 2 | 18.1 |
| A0A1B0GRY8 | Troponin I, fast muscle | TNNI2 | 23.66 | 13.95 | 2 | 20.2 |
| A2A6I8 | Troponin T, fast muscle | TNNT3 | 8.66 | 20.08 | 4 | 28.3 |
| A1BN54 | Alpha-actinin-1 | ACTN1 | 36.58 | 8.34 | 6 | 102.7 |
| Q9JI91 | Alpha-actinin-2 | ACTN2 | 13.09 | 7.83 | 6 | 103.8 |
| O88990 | Alpha-actinin-3 | ACTN3 | 11.30 | 5.11 | 4 | 103.0 |
| P57780 | Alpha-actinin-4 | ACTN4 | 65.92 | 20.39 | 14 | 104.9 |
| P31001 | Desmin | DES | 27.89 | 15.99 | 8 | 53.5 |
| P20152 | Vimentin | VIM | 72.37 | 24.89 | 8 | 53.7 |
| E9Q3W4 | Plectin | PLEC | 22.89 | 3.17 | 12 | 498.8 |
| P23927 | Alpha-B-crystallin | CRYAB | 14.36 | 36.57 | 7 | 20.1 |
| E9PYJ9 | LIM domain-binding protein 3 | LDB3 | 10.34 | 3.98 | 2 | 72.3 |
| Q9JIF9 | Myotilin | MYOT | 10.23 | 6.45 | 3 | 55.3 |
| A0A1L1STC6 | Nesprin-1 | SYNE1 | 4.29 | 0.31 | 2 | 1009.3 |
| A0A571BDS0 | Xin actin-binding repeat-containing protein 1 |
XIRP1 | 2.03 | 1.05 | 2 | 196.6 |
| Q8VHX6 | Filamin-C, muscle-specific |
FNLC | 21.04 | 2.53 | 6 | 290.9 |
| Z4YJF5 | Myomesin-1 | MYOM1 | 2.09 | 0.83 | 1 | 175.4 |
| A2ABU4 | Myomesin-3, slow, extraocular muscle | MYOM3 | 5.42 | 2.08 | 2 | 161.7 |
| P07310 | Creatine kinase, muscle-type | CKM | 48.98 | 29.92 | 11 | 43.0 |
| Q9R0Y5 | Adenylate kinase, AK1 | AK1 | 17.30 | 16.49 | 2 | 21.5 |
| P97447 | Skeletal muscle LIM-protein 1 | FHL1 | 10.47 | 5.89 | 2 | 61.8 |
| P21550 | Beta-enolase, muscle-specific |
ENO3 | 152.38 | 42.63 | 18 | 47.0 |