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Diagram outlining the S-nitrosylation/denitrosylation pathway of proteins. During nitrosylation, nitric oxide (NO) induced by NOS binds to cysteine residues of target proteins. Conversely, during denitrosylation, thioredoxin reductase (TrxR) system and the S-nitrosoglutathione reductase (GSNOR) system remove the NO group from the S-nitrolsylated proteins.
