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. 2021 Jul 7;22(14):7297. doi: 10.3390/ijms22147297

Table 2.

Review of significant SNPs in the different studies.

Locus Gene(s) of Interest SNP Cases (N) Controls (N) RA OA Relative Risk p-Value Paper PMID
1p31.1 NEGR1 rs1620977 187,810 521,301 A G 1.027 10−8 (10−2) * 32959083
1p34.3 CSF3R rs1395455 187,810 521,301 A G 1.025 10−8 (10−2) * 32959083
1p36.12 WNT4 rs7521902 305 2710 A C 1.2 10−9 23142796
rs7521902 11,506 32,678 A C 1.18 10−15 24676469
rs4654783 2019 14,471 A G 1.21 10−9 23472165 **
rs2235529 2019 14,471 A G 1.29 10−9 23472165 **
rs7521902 4604 9393 A C 1.18 10−8 23104006
rs7521902 1044 4017 A C NA 10−5 23104006 **
rs7521902 998 783 A C 1.18 10−8 26337243
rs7521902 998 783 A C 1.3 10−3 26337243 **
rs7521902 23,671 68,894 A C 1.29 10−15 27470151
rs7739264 998 783 T C 1.14 10−7 26337243
rs7515106 3194 2057 C T 1.09 10−5 29608257 **
rs12037376 17,045 191,596 A G 1.16 10−17 28537267
rs7412010 35,474 267,505 C G 1.13 10−29 31649266
1p36.21 KAZN rs10928050 394 650 A G 1.31 10−2 30044155 **
1q25.1 TNR rs6680839 187,810 521,301 T C 0.975 10−10 (10−4) * 32959083
1q31.1 BRINP3 rs72740410 187,810 521,301 T C 1.048 10−8 (10−2) * 32959083
1q31.3 CRB1 rs12121863 187,810 521,301 A T 0.971 10−8 (10−2) * 32959083
1q42.13 RHOU rs801112 696 825 A T 1.65 10−6 20844546
2p14 ETAA1 rs6546324 998 191,596 A C 1.08 10−9 28537267
rs4141819 4604 9393 C T 1.15 10−8 23104006
rs4141819 1044 4017 C T NA 10−2 23104006 **
rs4141819 11,506 32,678 C T 1.08 10−6 24676469
rs4141819 315 406 C T 1.35 10−2 30010178 **
2p14 MEIS1 rs11692361 1448 1540 C T 0.70 10−7 27506219
2p25.1 GREB1 rs13394619 11,506 32,678 G A 1.13 10−8 24676469
rs13394619 998 783 G A 1.15 10−9 26337243
rs13394619 998 783 G A 1.13 10−2 26337243 **
rs13394619 7164 21,005 A G 0.89 10−9 28900119
rs13394619 4604 9393 A G 1.15 10−8 23104006
rs13394619 1044 4017 A G NA 10−3 23104006 **
rs11674184 17,045 191,596 T G 1.13 10−17 28537267
rs77294520 17,045 191,596 C G 1.16 10−13 28537267
rs35417544 35,474 267,505 T C 1.09 10−13 31649266
2q13 IL1A rs6542095 696 825 C T 1.5 10−6 20844546
rs6542095 998 783 C T 1.22 10−10 26337243 **
rs6542095 998 783 C T 1.26 10−2 26337243
rs6542095 7164 21,005 T C 0.90 10−7 28900119
rs11677416 696 825 T A 2.0 10−6 20844546
rs10167914 17,045 191,596 G A 1.15 10−9 28537267
rs3783550 696 825 C A 1.51 10−6 20844546
rs3783525 696 825 A T 1.52 10−6 20844546
2q23.3 RND3 rs1519761 2019 14,471 C A 1.20 10−7 23472165 **
rs6734792 2019 14,471 G A 1.20 10−8 23472165 **
rs1519761 2019 14,471 G A 1.20 10−8 23472165 **
rs6757804 2019 14,471 G A 1.20 10−8 23472165 **
rs6734792 11,506 32,678 C T 1.10 10−6 24676469
2q35 FN1 rs1250241 17,045 191,596 T A 1.23 10−9 28537267
rs1250248 305 2710 A G 1.13 10−9 23142796
rs1250248 1129 831 A G 1.17 10−2 23315067 **
rs1250248 11,506 32,678 A G 1.11 10−4 24676469
3p13-3p12.3 PDZRN3-CNTN3 rs9865110 3194 2057 C A 1.1 10−6 29608257
3p21.31 KLHDC8B rs9586 187,810 521,301 T C 0.976 10−8 (10−4) * 32959083
3p21.31 IP6K1 rs9835157 187,810 521,301 A G 1.034 10−8 (10−4) * 32959083
3p21.31 CCDC36 rs6808036 187,810 521,301 T G 1.044 10−8 (10−5) * 32959083
3p25.1 LINC00620 rs6788293 187,810 521,301 T C 0.952 10−8 (10−2) * 32959083
4p14 KLF3-TLR10 rs10008492 3194 2057 T C 1.14 10−5 29608257
4p15.32 CC2D2A rs13118306 187,810 521,301 C G 0.977 10−8 (10−3) * 32959083
4q12 KDR rs1903068 17,045 191,596 A G 1.11 10−15 28537267
4q24 TACR3 rs2134025 187,810 521,301 A G 1.029 10−8 (10−4) * 32959083
4q28.2 SCLT1 rs12512642 187,810 521,301 T C 1.28 10−8 (10−2) * 32959083
5 NA rs966674 288 259 C G 2.95 10−3 25722978
5q13.1 ZNF366 rs4703908 288 259 C G 2.22 10−3 25722978
5q21.2 NUDT12 rs13164188 187,810 521,301 T C 1.025 10−9 (10−2) * 32959083
5q21.2 NUDT12 rs323509 187,810 521,301 A C 1.042 10−8 (10−2) * 32959083
6p11.2 PRIM2 rs1755833 3194 2057 A G 0.93 10−5 29608257
6p12.3 TFAP2D rs9349553 3194 2057 T C 1.09 10−6 29608257
6p21.1 RUNX2/SUPT3H rs227849 288 259 A G 2.31 10−3 25722978
6p21.33 C2 rs644045 171 2934 T C 1.90 10−10 28881265
6p22.1 TRIM26 rs116810322 187,810 521,301 T C 1.042 10−9 (10−5) 32959083
6p22.3 ID4 rs7739264 11,506 32,678 T C 1.11 10−10 24676469
rs7739264 4604 9393 T C 1.17 10−7 23104006
rs7739264 1044 4017 T C NA 10−4 23104006 **
rs7739264 998 783 T C 1.14 10−7 26337243
rs7739264 23,671 68,894 T C 1.10 10−10 27470151
rs760794 17,045 191,596 T C 1.17 10−7 28537267
rs6907340 2019 14,471 A G 1.12 10−7 23472165
6q12 ESY rs12206488 187,810 521,301 A G 0.976 10−9 (10−3) * 32959083
6q24.2 HIVEP2 rs2328370 187,810 521,301 A C 1.023 10−9 (10−3) * 32959083
6q25.1 CCDC170 rs1971256 17,045 191,596 C T 1.09 10−8 28537267
6q25.1 SYNE1 rs71575922 17,045 191,596 G C 1.11 10−8 28537267
rs17803970 17,045 191,596 A T 1.15 10−8 28537267
6q25.1-q25.2 ESR1 rs2206949 17,045 191,596 T C 1.10 10−7 28537267
rs58415480 35,474 267,505 C G 1.19 10−7 31649266
6q26 MAP3K4 rs144240142 3194 7060 T C 1.71 10−8 28333195
6q27 C6orf1 rs9347896 187,810 521,301 A G 1.29 10−8 (10−2) * 32959083
7p15.2 NFE2L3/HOXA10 rs12700667 3194 7060 A G 1.22 10−7 3019124
rs12700667 2392 2271 A G 1.17 10−3 3019124 **
rs12700667 4604 9393 A G 1.18 10−10 23104006
rs12700667 1044 4017 A G NA 10−9 23104006 **
rs12700667 998 783 A G 1.19 10−10 26337243
rs12700667 11,506 32,678 A G 1.13 10−9 24676469
rs12700667 17,045 191,596 A G 1.1 10−10 28537267
rs12700667 315 406 A G 1.3 10−2 30010178 **
7p22.3 C7orf50 rs10256972 1448 1540 A C 1.30 10−6 27506219
7q31.1 DNAJB9 rs11561993 187,810 521,301 T C 1.025 10−9 (10−3) * 32959083
8q24.21 GSDMC rs11784932 187,810 521,301 A C 1.026 10−8 (10−4) * 32959083
9p21.1 THEM215-APTX rs7042500 3194 2057 A G 0.9 10−5 29608257
9p21.1 ACO1 rs13299293 187,810 521,301 A T 0.976 10−9 (10−3) * 32959083
9p21.3 CDKN2B-AS1 rs10965235 1907 5292 C A 1.44 10−12 20601957
rs1537377 11,506 32,678 C T 1.12 10−8 24676469
rs1537377 17,045 191,596 T C 1.21 10−9 28537267
rs1537377 4604 9393 C T 1.15 10−6 23104006
rs1537377 1044 4017 C T NA 10−4 23104006 **
rs1448792 17,045 191,596 G A 1.08 10−8 28537267
rs10757272 17,045 191,596 C T 1.07 10−7 28537267
9p24.1-p23 PTRD rs2475335 3194 2057 T C 1.11 10−8 29608257
9p24.1-p23 PTPRD rs1931391 187,810 521,301 T G 1.031 10−8 (10−2) * 32959083
9q33.1 TRIM32 rs11793648 46,262 364,789 NA NA NA 10−6 32121467
10p13 CUBN rs1801232 7164 21,005 T G 0.86 10−7 28900119
10q11.21 HNRNPA3P1 rs10508881 2019 14,471 A G 1.19 10−7 23472165 **
10q11.21 LOC100130539
10q25.2 VTI1A rs2479037 288 259 C T 4.36 10−3 25722978
11p14.1 FSHB rs74485684 17,045 191,596 G A 1.11 10−8 28537267
rs11031006 35,474 267,505 A G 1,10 10−15 31649266
11p14.1 ARL14EP rs4071559 46,262 364,789 NA NA NA 10−7 32121467
11q14.3 TYR rs7933594 187,810 521,301 C G 1.024 10−9 (10−2) * 32959083
12p13.32 PARP11-CCND2 rs10459129 3194 2057 A G 0.9 10−5 29608257
12q21.32-12q21.33 KITLG-DUSP6 rs12303900 3194 2057 G T 1.28 10−7 29608257
12q22 VEZT rs10859871 11,506 32,678 C A 1.18 10−15 24676469
rs10859871 4604 9393 C A 1.20 10−9 23104006
rs10859871 23,671 68,894 C A 1.19 10−20 27470151
rs10859871 998 783 C A 1.16 10−7 26337243
rs10859871 1044 4017 C T NA 10−6 23104006 **
rs4762326 17,045 191,596 T C 1.08 10−8 28537267
13q21.1 PCDH17 rs9538160 187,810 521,301 A G 0.976 10−8 (10−3) * 32959083
13q22.2-13q22.3 LMO7-KCTD12 rs9530566 3194 2057 C A 1.08 10−5 29608257
14q23.2-14q23.2 PARP1P2/RHOJ rs10129516 171 2934 T C 3.01 10−10 28881265
15q26.2 NR2F2 rs35625885 187,810 521,301 A G 0.965 10−8 (10−2) * 32959083
15q26.3 IGF-1R rs4966038 1448 1540 C G 1.40 10−9 27506219
17p13.1 SLC35G6 rs9891297 46,262 364,789 NA NA NA 10−6 32121467
17q21.32 SKAP1 rs2278868 3194 2057 C T 0.92 10−6 29608257
17q24.1 CEP112 rs17693745 3194 2057 T C 1.08 10−5 29608257
19q12 ZNF536-TSHZ3 rs2198894 3194 2057 T C 1.09 10−5 29608257
20q13.33 LAMA5 rs2427284 394 650 A G 0.49 10−3 30044155 **

OA: Other allele, RA: Risk allele, PMID: Pubmed identifer, RS: refSNP, SNP: Single nucleotide polymorphism. * p value meta-analysis for depression and endometriosis study (p value for endometriosis), ** Results from replication studies.