Figure 3.

Summary of the markers included in the different predictive models developed in Edinburgh: the 4-gene classifier Edinburgh EndoResponse 4 (EER4) incorporates the expression level of 2 genes at pretreament (pre) and 2 genes after 2 weeks of neoadjuvant endocrine therapy (2w); this was simplified into the EndoAdjuvant2 (EA2) signature, which uses IHC assessment of the 2 main classifiers to stratify cases into discrete risk groups; EndoAdjuvant2 clinical (EA2clin) combined EA2 with clinical factors to produce a more accurate hybrid model.