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. 2021 Jul 5;10(7):1694. doi: 10.3390/cells10071694

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MPP⁺ toxicity reduces the levels of Lamin B1 and HMGB1, while it increases a cell arrester, p21 in N27 cells. The examples of cellular senescence markers are displayed in Western blots (A). The levels of LaminB1 (B), HMGB1 (C), SATB1 (D), p16 (E) and p21 (F) are displayed in comparison between MPP⁺ and vehicle treatment. Cellular senescence markers such as LaminB1 and HMGB1 were reduced, but p16 and p21 were enhanced by MPP⁺ treatment. GAPDH was adopted as a loading control. ImageJ was used for the analyses of band intensities, and relative levels (100% for vehicle) are displayed in mean ± SEM and applied to unpaired Student’s t-test for statistical significance. *: p < 0.05, **: p < 0.01 and ***: p < 0.001. ns: not significant.